Bladder C Support Set of 6

Bladder Cancer is not as common as the incontinence and kidney problems that arise due to ageing, structural prolapse and/or chronic infection in dogs. 

There are two types of bladder cancer: transitional cell carcinoma (TCC) and urothelial carcinoma (UC)

These tumours will start in the urinary tract, but can spread (metastasise) to other parts of the body, including the bone, liver, kidney, spleen, and skin(1). It is relatively rare but is beginning to appear more regularly and a correct diagnosis is sometimes delayed while trying to treat symptoms misdiagnosed as simple infection.

Some breeds are more likely to develop bladder cancer including Scottish Terriers, West Highland White Terriers, Beagles, Shetland Sheepdogs, Wire Fox Terriers and American Eskimo Dog (1).

Some studies have suggested that chronic exposure to certain chemicals (petrochemicals, pesticides, herbicides) may increase the risk for a dog to develop bladder cancer so trying to avoid freshly sprayed lawn or verges on the street. Avoid chemical flea drops sprays and bombs etc

Signs of bladder cancer in dogs

• Small, frequent urination
• Blood in urine
• Incontinence
• Appears to be painful for the dog to urinate

There's several ways that bladder cancer can be diagnosed.

Diagnostic methods include urinalysis, blood test, Veterinary Bladder Tumor Antigen (VBTA) Test, X-rays or ultrasounds or a biopsy.

Natural Pet Botanicals Recommendations formulas are both effective and gentle in supporting the whole body, you treat your own animal or pet at home, and in almost every single case we improve vitality and longevity. If you are dealing with any metabolic or immune issue with your pet, we suggest that you contact us for a consultation so we can ensure you are using the right products

* Natural pet botanicals are not intended to replace veterinary care or medication. Our formulas are offered as an alternative health support for your animal's condition and not as a cure. All our oral supplements are to be consumed voluntarily by your animal in food, treats or liquid.

INGREDIENTS AND BENEFITS

Formula 1.  
Astaxanthin (Microalgae Haematococcus pluvialis 1X) (Scientific studies reviewed the role of ROS in the various stages of cancer development and provided evidence that astaxanthin, derived from nature, are highly effective in eliminating cancer cells. Astaxanthin is used as a dietary supplement for human, animal, and aquaculture consumption)
Minerals Turp (Terebinthina Oleum 200C) (traditionally used for bleeding)
Potassium Hydrate (Causticum 200C)
Rhus Aroma 1M (traditionally used for bladder or kidney hemorrhages)
Arbor Vitae (Thuja 200C)
Spanish Fly (Cantharis 200C) (traditionally used for bladder, cystitis blockage infection, bleeds)
Arseniate of Gold (Aurum Ar 200C) (traditionally used for bladder carcinoma)
Dandelion (Taxacum 1M) (traditionally used for bladder cancer)
Ruta whole plant (Ruta 6C)
Calcarea Phosphorica (Calc Phos 30X)
Glacial Acetic  (Aceticum Acidum 200C) (traditionally used for skin growths, stomach growths, hemorrhages from nose, lungs, stomach, bowels, uterus.  Edema -fluid build up) 
Yarrow whole plant (Millefolium 12X) (traditionally used for passive or active hemorrhaging, anemia, growths)
Chlorhydrate mineral (Histaminum Mur 12X)
Condor plant (Cundurango) (traditionally used as a lymph drainer, stomach, ulcer, breast, tongue growths, stricture of the esophagus)
Bladda Clear 15 formula (traditionally used to promote flow of urine easily)
Reference: https://www.researchgate.net/publication/256090732_Ruta_graveolens_from_Traditional_System_of_Medicine_to_Modern_Pharmacology_an_Overview
Reference: http://cms.herbalgram.org/expandedE/Yarrow.html
CANCER  RESEARCH
https://pubmed.ncbi.nlm.nih.gov/10798217/
Antitumor activity of astaxanthin and its mode of action – PubMed (nih.gov)
https://pubmed.ncbi.nlm.nih.gov/10470126/
A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo – PubMed (nih.gov)
https://www.timesgazette.com/2020/03/04/is-it-a-cure-for-cancer-and-more/
Is it a cure for cancer and more? – The Times Gazette

Formula 2.
Astaxanthin  (Microalgae Haematococcus pluvialis 30C, 1X)
CANCER RESEARCH
https://pubmed.ncbi.nlm.nih.gov/10798217/
Antitumor activity of astaxanthin and its mode of action – PubMed (nih.gov)
https://www.sciencedirect.com/science/article/abs/pii/S0024320502015229
Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress – ScienceDirect
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515619/
Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin – PMC (nih.gov)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266165/
Astaxanthin Prevents Human Papillomavirus L1 Protein Binding in Human Sperm Membranes – PMC (nih.gov)
https://pubmed.ncbi.nlm.nih.gov/22080479/
Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma – PubMed (nih.gov)
https://pubmed.ncbi.nlm.nih.gov/30287735/
Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro – PubMed (nih.gov)
https://pubmed.ncbi.nlm.nih.gov/33179051/
The Promising Effects of Astaxanthin on Lung Diseases – PubMed (nih.gov)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459748/
Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer – PMC (nih.gov)
https://pubmed.ncbi.nlm.nih.gov/31407778/
The conundrum of dietary antioxidants in cancer chemotherapy – PubMed (nih.gov)    

Formula 3.
Blue Flag  (Iris Versicolor)
Wild Indigo (Baptisia)
Violet Leaves (Viola Odorata)
Red Clover (Trifolium pretense)
Parsley (petrolelinum crispum)  
Comfrey (Symphytum officinale) 
Cleaver Root (Galium aparine)
Poke Root (Phytolacca americana)
Japanese Knotweed Root (Persicaria capitata)
French Maritime Pine (Pinus pinaster)
*Research and Studies done on these herbs used 
Violet Leaves (Viola Odorata) has been used for centuries as a blood purifier. As a blood cleanser may have some effects in warding off infection; uncontaminated blood may promote a higher resistance to disease and infection. A certain research showed that violet leaves are beneficial to prevent and treat the early stage of cancer. It’d due to the high antioxidant level which is able to fight the free radicals as the main factor of cancer growth. The regular consumption of violet leaves is evidently able to reduce or shrink the early stage or tumor and cancer. 
*Reference:  Viola odorata as a medical herb is used in liver disorders and relieving cancer pain. 
*Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937098/
*Reference: https://drhealthbenefits.com/herbal/leaves/health-benefits-violet-leaves
*Reference: https://achs.edu/blog/2022/07/08/science-supports-violas-traditional-medicinal-value/
Blue Flag (Iris Versicolor) herb has numerous medicinal properties. It is not only helpful in aiding the purifying of the blood through the liver, and to increase bile production, but it also helps our spleen and the glands in our lymphatic system. It has high detoxifying properties and is mainly used to remove the toxic substances in the body.
Comfrey (Symphytum officinale) has several medicinal actions. It is known as a vulnerary and as an astringent. These properties make it useful in the healing of minor wounds, both internal and external. Comfrey can be used for minor injuries of the skin, where it will work to increase cell production, causing wounds to heal over rapidly. It can be used internally for stomach and duodenal ulcers, where it will have the same effect. Comfrey is also demulcent, producing a mucilage that coats and soothes irritated tissues. It will help reduce inflammation, and at the same time lessen scarring. Comfrey also has expectorant properties and has a relaxing effect on the respiratory membranes. Since it helps relax and soothe membranes, it is useful in coughs, asthma, and bronchitis. As an astringent, comfrey can also help control slow bleeding, as in the case of ulcers. 
*Reference: https://www.researchgate.net/publication/221855881_Comfrey_A_Clinical_Overview
Red clover (Trifolium pretense) is widely used in traditional medicine as a remedy for menopause symptoms, asthma, whooping cough, arthritis, and even cancer. Has metabolic diuretic (stimulates the removal of waste and water from the kidneys), lymphatic (stimulates lymph movement) and expectorant (supports elimination of mucus from the lungs) properties. Because of these characteristics, red clover has been described as a 'blood purifier'.
*Reference: https://pubmed.ncbi.nlm.nih.gov/24312387. It has affinities with the respiratory, circulatory and lymphatic systems and is known as a relaxing expectorant and a "blood cleanser". It has a reputation as a remedy for coughs, skin issues, & lymphatic indications. Also Trifolium is useful for any chronic condition of toxicity, enhances the detoxification functions of the liver. The alterative properties of Trifolium give this herb great usefulness in the treatment of skin conditions.  It is of value in recurrent boils or acne, eczema, and psoriasis. Trifolium exerts some of the strongest phytoestrogenic effects among medicinal plants. Valuable for menopausal women because of its phyotoestrogenic and mineral constituents.
*Reference: http://www.naturalmedicinalherbs.net/include/searchherb.php?herbsearch=red+clover&x=0&y=0
Cleavers Root (Galium aparine) Cleavers is believed to support the immune system and have diuretic, antispasmodic, and anti-inflammatory effects. In addition to research on cancer, cleavers has been used on skin conditions, like psoriasis. University of California Agriculture and Natural Resources, Statewide Integrated Pest Management Program.
*Reference: https://www.indigo-herbs.co.uk/natural-health-guide/benefits/cleavers  Cancer - Immunomodulators are bioactive substances that support the body's natural defenses in fighting against pre-cancerous cells. According to the American Cancer Society, "Immunomodulators are a group of drugs that mainly target the pathways that treat multiple myeloma and a few other cancers. They have many ways to work, including working on the immune system directly by turning down some proteins and turning up others". 4 Although more human studies are needed, cleavers has been shown to act as an immunomodulator by promoting the proliferation of lymphocytes (a type of white blood cell). This effect suggests the potential for immune system benefits and cancer cell reduction. 1 In addition, studies on two human tumor cells, MCF-7 and Caco-2, demonstrate the ability of cleavers extract to inhibit cancer cell growth through apoptosis (programmed cell death). 5 Of course, looking at isolated effects in the lab can't always predict what will happen in the human body, however, these results are promising for the future of breast and colon cancer research.
*Reference: https://www.verywellhealth.com/colon-cancer-4014742. Cleavers is also listed as an immunomodulatory active herb influencing the defense response of the human body. Similarly, disorders of the blood are about more than just the bone marrow. For instance, hyperlipidemia in people is surely not just a problem with the blood - it is a lifestyle problem in many cases. Although this section is all about blood and immune disorders, every condition that is listed requires a global approach to treatment. Herbs inherently provide complex actions that address more than one deranged process in the body. Mechanisms of Interest - Adaptogens - These plants have been noted both traditionally and in human clinical trials and animal studies to increase resistance to stress, which predisposes animals to disease, including infection. Adaptogens generally work by modulating the hypothalamic-pituitary-adrenal axis, but many have other effects as well, such as modulation of immune function.
*Reference:  Immunomodulatory Activity and Phytochemical Profile of Infusions from Cleavers Herb https://pubmed.ncbi.nlm.nih.gov/32824103/
French Maritime Pine Bark (Pinus pinaster) Pycnogenol’s Unique Composition.  Pycnogenol French maritime pine bark extract is a naturally programmed combination with constant proportions of procyanidins, bioflavonoids and organic acids, which offer amazing natural properties. Maritime Pine Bark is used in our formulas to support a wide range of illnesses. It has been used for hundreds of years and works synergisticly as a potent antioxidant along with Vitamins C and E, to support cardiovascular health. - A powerful antioxidant Maritime Pine Bark is a natural antioxidant. It is an excellent source of flavonoids and has anti-inflammatory properties that work to protect the body from harmful free radicals, helps boost the immune system and strengthens blood vessel walls and capillaries. This specialist antioxidant is nearly 25 times more powerful than Vitamin C! It also boosts how the body uses Vitamin C. - Fight off a common cold Maritime Pine Bark was able to reduce the duration (i.e. the number of days) and severity (i.e. the intensity of the symptoms you experience) of colds in a study. Lost working days were significantly decreased in the group that was supplementing and 'significantly reduced the number of complications'. They also showed that there was less need to use other compounds whilst using the Maritime Pine Bark. - Balance blood sugars Maritime Pine Bark showed that it could reduce high blood sugar and help with pre-diabetes, or diabetes. Participants in the tests found improvement in blood sugar control when pine bark extract was combined with diabetic medications. In the studies the insulin levels didn't change, but glucose levels were reduced. - Improve cognitive function there’s evidence that Maritime Pine Bark may be a promising nootropic for various groups of people, including middle-aged professionals, students, and people with mild cognitive decline like brain fog. A clinical trial of 60 health professionals found that Maritime Pine Bark extract (150 mg/day) improved cognitive function. This included attention levels, alertness and performance. Research also showed sustained attention, memory, executive functions, mood, and reduce oxidative stress. - Reduce Allergies In studies where the participants took Maritime Pine Bark for at least 5 weeks prior to flu season, it was shown to reduce hay fever symptoms. In another clinical trial of 76 people with allergic asthma, the extract may reduce symptom scores and circulating leukotrienes are reduced and lung function was improved. - Improve exercise and physical performance Pine bark extract has a significant impact on nitric oxide (NO) levels in the body, which are responsible for vasodilation and improving blood flow. It also showed promising result to decrease free radicals in the body after exercise (which cause muscle fatigue and damage). It also reduced muscle cramps and pain.
*References: Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract - S. Iravani and B. Zolfaghari, PhD. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203267/ A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. https://www.ncbi.nlm.nih.gov/pubmed/11996210 Pine bark extract is a potent antioxidant, and may help boost the effects of vitamin C and other antioxidants,    http://www.berkeley.edu/news/media/releases/98legacy/02_05_98a.html
7 Health Benefits of Maritime Pine Bark  https://www.naturesfare.com/health/7-health-benefits-pine-bark-extract/
Pycnogenol improves cognitive function, attention, mental performance and specific professional skills in healthy professionals aged 35-55
https://www.ncbi.nlm.nih.gov/pubmed/24675223  Improvement of common cold with Pycnogenol®: a Winter registry study https://www.ncbi.nlm.nih.gov/pubmed/24675223Pycnogenol  French maritime pine bark extract’s unique blend of active compounds has four basic properties – it’s a powerful antioxidant, in fact it is 20 times more potent than Vitamin C and 50 times more potent than Vitamin E, acts as a natural anti-inflammatory, helps generate collagen and hyaluronic acid, and aids in the production of endothelial nitric oxide which hary syndrome, and obesity. It is also used for conditions that affect heart health such as "hardening of the arteries" (atherosclerosis) and for high blood levels of certain fats including cholesterol and triglycerides.   Fenugreek is used for kidney ailments, a vitamin deficiency disease called beriberi, mouth ulcers, boils, bronchitis, infection of the tissues beneath the surface of the skin (cellulitis), tuberculosis, chronic coughs, chapped lips, baldness, cancer, Parkinson's disease, and exercise performance.
*Reference:  https://www.healthline.com/nutrition/pine-bark-extract
Japanese Knotweed Root (Persicaria capitata) - is a resveratrol extract derived from organic Japanese knotweed & organic whole grapes.Resveratrol stands out. Actually, it performs even better than vitamin C when it comes to neutralizing free radicals.  Resveratrol shares many benefits with bioflavonoids, a group of plant-derived compounds with antioxidant properties. In addition to being an antioxidant, resveratrol is also an anti-inflammatory, anticarcinogenic, cardioprotective, vasorelaxant, phytoestrogenic and neuroprotective agent (Source). Randomized, controlled trials have shown that resveratrol supplementation supports healthy weight management, blood-sugar metabolism, cardiovascular function, mood, healthy inflammatory balance and oxidative stress.
* Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705504/
Parsley (petrolelinum crispum)   Parsley has been used as carminative, gastro tonic, diuretic, antiseptic of urinary tract, anti-urolithiasis, anti-dote and anti-inflammatory and for the treatment of amenorrhea, dysmenorrhea, gastrointestinal disorder, hypertension, cardiac disease, urinary disease, otitis, sniffle, diabetes and also various dermal disease in traditional and folklore medicines. Phenolic compounds and flavonoids particularly apigenin, apiin and 6"-Acetylapiin; essential oil mainly myristicin and apiol; and also coumarins are the active compounds identified in Petroselinum crispum. Wide range of pharmacological activity including antioxidant, hepatoprotective, brain protective, anti-diabetic, analgesic, spasmolytic, immunosuppressant, anti-platelet, gastroprotective, cytoprotective, laxative, estrogenic, diuretic, hypotensive, antibacterial and antifungal activities have been exhibited for this plant in modern medicine.
Reference: https://pubmed.ncbi.nlm.nih.gov/24660617/
Poke Root (Phytolacca americana) the benefits of Poke root have long been documented and its biggest effect is believed to be its influence on the lymphatic system. By stimulating the immune system you are providing a great way to help fight this and other disease. 
*Reference: https://www.healthline.com/health/poke-root  *Reference: https://pubmed.ncbi.nlm.nih.gov/12639929/
*Reference: https://pubmed.ncbi.nlm.nih.gov/15026348/
Wild Indigo (Baptisia tinctoria) helps clean the lymphatic system and also says ...   rid the body of any damaging microbes and wastes. It improves the flow of lymph and reduces glandular swelling.  Also the treatment of enlarged and inflamed lymph glands and also to reduce fevers systemically may be helpful in the treatment of enlarged and inflamed lymph glands, reduction of fevers and an anti-infective.
* Reference: http://www.nat